Working digitally is fantastic for so many reasons but it can sometimes result in your art lacking the tooth of traditional artwork.
If you do artwork digitally, or color scans of your traditional art and digitally color them, you may have run into this. Your line work (if you're a line artist) is the way you want it, you have an eye catching color palette, your composition is dynamic, but there's something about it that still feels just a little off. So you've made a great illustration in Clip Studio Paint or Photoshop.